DNA copy number variations in drug reaction with eosinophilia and systemic symptoms (DRESS) identifying 2 new candidates genes
نویسندگان
چکیده
Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe cutaneous drug adverse reaction (SCAR) with a not well known pathogenesis. Strong genetic associations between HLA groups and drug allergy have been reported but seem to be specific for a type of SCAR, one drug and an ethnic group. Using a pangenomic approach, effective even on a small effective, by an innovating method, the Comparative Genomic Hybridization (CGH) technique the objective of this study was to determine whether some copy number variations (CNV) were associated with the occurrence of DRESS while studying only well-defined DRESS patients.
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